Leaky Gut Testing

Intestinal permeability, or leaky gut, is a pandemic in and of itself.  They say all disease start in the gut which I will argue for here.  But first, let's understand why gut health is so important.

Your small intestine is where all of your food is absorbed.  By the time your food gets to your small intestine it should have already been thoroughly chewed, carbohydrates broken down by the enzyme amylase in your salvia, and hydrochloric acid in your stomach should have begun the process of breaking everything else down.  Shortly after your stomach empties its contents into your small intestine, all that food is met with more pancreatic enzymes, protease and lipase to break down proteins and fat, and bile from your gallbladder to help break down fats even more.  

Your small intestine is incredibly thin, just one cell wall thick, almost like a sausage casing.  These cells are joined to one another by tight junctions.  Small food particles then pass through each cell where the nutrients are extracted and shuttled into your blood stream to go on to serve the rest of your body with nutrients.  However, sometimes these tight junctions lose their tightness and gaps start to form between them.  This is due to inflammatory chemicals and foods like dairy, gluten, and sugar.  Incompletely digested food and chemicals are, therefore, able to pass through unencumbered on into your blood stream.  Because these larger food molecules don't look like normal nutrients, your immune system mounts an attack against them.  If your tight junctions never tighten back up, and you keep consuming inflammatory foods you are sensitive to your immune system will never turn off its attack.  This is the basis of an autoimmune disease.  

So how does all disease start in the gut?

Some diseases are inherited and you are born with them before your gut even had a chance to work for the first time.  But this is an extremely small number compared to our modern diseases.  All other disease is either due to infection, deficiency, or inflammation.  

 

Infection

The majority of your immune system can be found in the gut because thats the route of entry for most pathogens.  A leaky gut triggers an immune response as described above.  This immune response depletes nutrients for future immune responses, but also keeps the immune system busy attacking food instead of an actual pathogen!  Poor gut health also damages your gut microbiome.  Less beneficial bacteria to help control the bad.  

Deficiency

Leaky guts have malabsorption issues.  Poor nutrient absorption leaves less building blocks for your body to make proteins, hormones, and neurotransmitters on top of less fuel for your cells to operate.  

Inflammation

Inflammation is the root of all evil.  It causes pain, chronic disease, psychological issues and neurodegeneration, structural abnormalities, and autoimmune diseases.  Inflammation is a cause of intestinal permeability and intestinal impermeability is a cause of inflammation.  Not to mention that a leaky gut leads to a leaky brain which makes treating the gut a treatment for depression, anxiety, ADHD, and many many more.  

Intestinal permeability is, unfortunately, very common.  Most don't know they have it because they've lived their whole lives with it.  These are the ones who don't know how good they truly can feel, what conditions of theirs can be treated, and what diseases can be prevented.  

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The Intestinal Antigenic Permeability Screen from Cyrex Laboratories

  • The most accurate test for intestinal permeability 

  • Tests for antibodies for actomyosin, occludin, zonulin, and lipopolysaccharides against IgA, IgG, and IgM

    • Actomyosin​

      • A protein network responsible for regulating intestinal barrier integrity by maintaining the ​plasticity of tight junctions.  

    • Occludin​

      • A main component of proteins holding tight junctions together. ​

    • Zonulin​

      • Regulates the permeability of the intestines​

    • Lipopolysaccharides ​​​

      • Toxins released by ​bacteria which damage the intestines, making them more permeable.  

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

This test is a great first step in determining if your gut is contributing to your health or contributing to your disease.  

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The test kit can be sent to you anywhere in the country.  All you have to do is take it to a blood draw site near you for collection and then mail it in with the prepaid label!